Manuela Basso
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Formazione |
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01/09/2003 – 14/03/2008 Doctor of Philosophy (PhD) in Life Science, The Open University Milton Keynes/UK 01/09/1997 – 08/10/2002 Master of Science in Medical Biotechnology, School of Medicine, University of Torino, Torino, Italy
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Carriera accademica ed attività didattica |
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Education 2008 Doctor of Philosophy (PhD) in Life Science The Open University Milton Keynes, UK and the Institute of Pharmacological Research Mario Negri, Milan, Italy Supervisors: Pamela Shaw and Valentina Bonetto 2002 Master of Science in Medical Biotechnology School of Medicine, University of Torino, Torino, Italy Final grade: 110/110 cum laude and honors
Current Position 30/10/2018-Present Assistant Professor, Ricercatore Linea B. Department of Cellular, Computational and Integrative Biology University of Trento/Italy
Past positions 2013 – 2018 Assistant Professor, Ricercatore Linea A. Department of Cellular, Computational and Integrative Biology - CIBIO University of Trento/Italy 2012-2013 Instructor The Brain and Mind Institute, Cornell University, NY, USA PI: Dr. Rajiv R. Ratan Transcriptional biology and neurobiology 2009-2012 Postdoctoral Fellow Burke-Cornell Medical Research Institute PI: Dr. Rajiv R. Ratan Neurobiology; Homeostasis 2008 Visiting Scientist Burke-Cornell Medical Research Institute PI: Dr. Alvaro Estevez Motor neuron biology |
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Interessi di ricerca |
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The laboratory is generally interested in deciphering the pro-survival mechanisms linked to neuronal activity and the neuronal adaptive response to stress. At the moment, we are investigating the pathological processes occurring in two motor diseases: Amyotrophic Lateral Sclerosis (ALS) and Spinal and bulbar Muscle Atrophy (SBMA). We are keen in understanding the intercellular mis(communication) between different cellular populations in the central nervous system and periphery |
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Attività di ricerca |
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http://web.unitn.it/en/cibio/32974/laboratory-of-transcriptional-neurobiology |
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Appartenenza a società e comitati scientifici |
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2018-present Member of the Associazione Italiana di Biologia e Genetica (AIBG) 2016-present Member of the Italian Society of Neuroscience 2008- 2013 Member, Society for Neuroscience 2013 Member, International Society for Neurochemistry 2012 Member, ISSNAF - Italian Scientists and Scholars in North America Foundation 2008- 2013 Member, New York Academy of Sciences 2001-2003 Member, Italian Association for the Cure of Parkinson’s disease |
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Premi e riconoscimenti |
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2019 Best poster award at the Decennale ARISLA, Milan, Italy 2017 Recipient of the Trampoline grant 2016 from the French Muscular Dystrophy Association (AFM, France) 2017 Recipient of the Marie Sklodowska-Curie Individual Fellowship (RI panel) 2016 Recipient of the Young Investigator Award from the Kennedy’s disease association (USA) 2016 Travel award, National ataxia Foundation meeting, Orlando, USA 2015 Travel award for the Italian Symposium on Neuroscience (SINS), Cagliari, Italy 2013 Travel award for the International Society of Neurochemistry, Cancun, Mexico and selected speaker for the Young Investigator Colloquia. 2012 Poster award at the annual Burke Research Medical Institute contest, Weill Medical College, Cornell University, White Plains, NY, USA 2006 -2007 PhD (Leonardi) Fellowship, Mario Negri Institute, Milan, Italy 2003-2006 PhD Fellowship from the Dulbecco Telethon Institute, Italy 2002 Magna cum laude and Honors, University of Torino, Italy |
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Convegni e conferenze |
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List of Invited or selected Speaker at Conferences, Workshops and Seminars November 2019: Intercellular miscommunication in the brain and periphery: characterization of extracellular vesicle in Amyotrophic Lateral Sclerosis. EVITA, Palermo, Italy. April 2019: Extracellular vesicles and the intercellular communication in neurodegenerative disease. Spring Meeting. University of Ulm. Germany. April 2019: Arginine methylation: a novel post translational modification that impacts huntingtin function in Huntington’s disease. Seminar series. Burke neurological institute, White Plains, NY, USA March 2019: Characterization of plasma extracellular vesicles as a mean for patient profiling. Workshop on Converging micro-nano-bio technologies towards integrated biomedical systems, Roncegno (TN), Italy February 2019: Targeting PRMT6 to attenuate spinal and bulbar muscular atrophy: a silencing approach. Toward a European Consortium for SBMA. European Neuromuscular Centre. Amsterdam, The Netherlands. June 2018: Beyond TG2 in Neurodegeneration - TG6 Loss and Gain of Function in Spinocerebellar Ataxia 35. Transglutaminases in Human Disease Processes. Gordon Research Conference. Switzerland. February 2017: Extracellular RNA and biomarker discovery: the contribution of extracellular vesicles. miRNA DisEASY –Workshop. Trento. June 2016: Role of extracellular vesicles and their associated cargos in health and disease. EMBO course. Regulatory small and long non-coding RNAs: Durat et Lucet. October 2015: Effect of class I HDAC inhibition in R6/2 mice, a model of Huntington’s disease. SINS, Cagliari. October 2015: Extracellular vesicles in ALS. SINS, Cagliari. March 2015: Transglutaminases and the neuronal adaptive response. University of Nottingham, UK. July 2014: Understanding transglutaminase upregulation in neuronal stress. Gordon Research Conference “Transglutaminase in Human Disease Conditions” 2014, Il Ciocco, Italy. April 2013: Transglutaminase inhibition abrogates oxidative stress-mediated and excitotoxic death: a new epigenetic modulator on the CNS block. ISN 2013, Cancun. December 2012: University of Trento. Transglutaminase 2 as a novel candidate modulator of metabolic gene transcription. October 2012: University of Kansas. Transglutaminase 2 as a novel candidate modulator of metabolic gene transcription. July 2012: Transglutaminase in the nucleus: novel targets for an old enzyme. Gordon Research Conference “Transglutaminase in Human Disease Conditions” 2012, Davidson College, NC. September 2011: 5th Neurodegenerative Conditions Research and Development 2011, San Francisco, CA. Adaptation to Mitochondrial Dysfunction in Alzheimer's Disease and Huntington's Disease Via Inhibition of Transglutaminase 2. June 2006: ENCALS meeting, The Netherlands. June 2005: Busto Proteomica, Seconda Giornata di Studio e Discussione sulla Proteomica applicata alla Ricerca Biomedica, Università dell’Insubria, Busto Arsizio (VA), Italia. |
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Altre attività |
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Commissions of Trust 2020 Editorial board: Scientific Reports, Frontiers in Genetics, Frontiers in Aging Reviewer for the Journal: Brain, Scientific Reports, Glia Reviewer for the grant agency: The MNDA, The UK dystrophy association, AFM Telethon 2019 Editorial board: Scientific Reports, Frontiers in Genetics Reviewer for the Journal: Brain, Scientific Reports, Stem Cell Reviews, Neuroscience, Glia, The Journal of Neuroscience Research, The Journal of Neuroscience Reviewer for the grant agency: Alzheimer’s association, Marie Sklodowska-Curie Individual fellowships 2018 Reviewer for the Journal: Brain, Annals of Clinical and Translational Neurology, Neurochemistry International, Neuroscience, The American Journal of Pathology, Brain Research Bulletin, The Journal of Neuroscience, Disease Markers Reviewer for the grant agency: Alzheimer’s association 2017 Reviewer for the Journal: Neuroscience, Molecular Cellular Neuroscience, Neuroinflammation, Scientific Reports, The Journal of Neuroscience, Drug Discovery Today, Molecular Neurobiology, Frontiers Neuroscience. Reviewer for the grant agency: The Downhill Medical Trust (UK), MND Association (UK), Human Frontiers HFSP Fellowships (France) 2016 Reviewer for the Journal: Neuroscience, Biomaterials, Experimental Neurology, Scientific Reports Reviewer for the grant agency: Thierry Latran, Alzheimer’s Association 2015 Reviewer for the Journal: eNeuro, Neuroscience, Glia, Experimental Neurology Reviewer for the grant agency: Alzheimer’s Association 2014 Reviewer for the Journal: Proteomics, Journal of Developmental Neuroscience, La Prensa Medica, The Journal of Neuroscience, Cell Death & Differentiation Reviewer for the grant agency: Alzheimer’s Association 2012-2013 Reviewer for the Journal: The Journal of Neuroscience, Antioxidants & Redox Signaling, Cell Biology and Toxicology, British Journal of Pharmacology, Molecular and Cellular Neuroscience, FASEB Journal, Amino Acids, Recent patents on CNS drug discovery 2012-2013 Reviewer for the grant agency: Alzheimer’s Association (2012 and 2013), Croatian Science Foundation (2012), Italian Ministry of Education (PRIN and Future and Research 2013), Thierry Latran (ALS Foundation) 2009-2012 Reviewer for the Journal: Journal of Neuroscience, Neurobiology of Disease, Antioxidants & Redox Signaling, Neuroscience
Institutional responsabilities 2018-Present Coordinator of the Master degree in Cellular and Molecular Biotechnology, University of Trento 2018 Organizer of the meetings from the Bench to the Clinics (monthly seminars between Academia and the local Hospital) 2014-2018 CIBIO Delegate for the Linguistic Centre of the Ateneum (CLA) 2013-Present Faculty at the University of Trento, Dep. CIBIO 2012-2013 Instructor at the Weill Medical College, Cornell University, NY, USA |