|
Year
|
Volume
|
Number
|
Holdings
|
|
|
|
|
2015
|
58
|
24
December 24
|
Yes
|
|
|
|
|
2015
|
58
|
23
December 10
|
Yes
|
|
|
|
|
2015
|
58
|
22
November 26
|
Yes
|
|
|
|
|
2015
|
58
|
21
November 12
|
Yes
|
|
|
|
|
2015
|
58
|
20
October 22
|
Yes
|
|
|
|
|
2015
|
58
|
19
October 8
|
Yes
|
|
|
|
|
2015
|
58
|
18
September 24
|
Yes
|
|
|
|
|
2015
|
58
|
17
September 10
|
Yes
|
|
|
|
|
2015
|
58
|
16
August 27
|
Yes
|
|
|
|
|
2015
|
58
|
15
August 13
|
Yes
|
|
|
|
|
2015
|
58
|
14
July 23
|
Yes
|
|
|
|
|
2015
|
58
|
13
July 9
|
Yes
|
|
|
|
|
2015
|
58
|
12
June 25
|
Yes
|
|
|
|
|
2015
|
58
|
11
June 11
|
Yes
|
|
|
|
|
2015
|
58
|
10
May 28
|
Yes
|
|
|
|
|
2015
|
58
|
9
May 14
|
Yes
|
|
|
|
|
2015
|
58
|
8
April 23
|
Yes
|
|
|
|
|
2015
|
58
|
7
April 9
|
Yes
|
|
|
|
|
2015
|
58
|
6
March 26
|
Yes
|
|
|
|
|
2015
|
58
|
5
March 12
|
Yes
|
|
|
|
|
2015
|
58
|
4
February 26
|
Yes
|
|
|
|
|
2015
|
58
|
3
February 12
|
Yes
|
|
|
|
|
2015
|
58
|
2
January 22
|
Yes
|
|
|
|
|
2015
|
58
|
1
January 8. - New Frontiers in Kinases: Second Generation Inhibitors
|
Yes
|
|
|
|
|
2014
|
57
|
24
December 26
|
Yes
|
|
|
|
|
2014
|
57
|
23
December 11
|
Yes
|
|
|
|
|
2014
|
57
|
22
November 26
|
Yes
|
|
|
|
|
2014
|
57
|
21
November 13
|
Yes
|
|
|
|
|
2014
|
57
|
20
October 23
|
Yes
|
|
|
|
|
2014
|
57
|
19
October 9
|
Yes
|
|
|
|
|
2014
|
57
|
18
September 25
|
Yes
|
|
|
|
|
2014
|
57
|
17
September 11
|
Yes
|
|
|
|
|
2014
|
57
|
16
August 28
|
Yes
|
|
|
|
|
2014
|
57
|
15
August 14
|
Yes
|
|
|
|
|
2014
|
57
|
14
July 24
|
Yes
|
|
|
|
|
2014
|
57
|
13
July 10
|
Yes
|
|
|
|
|
2014
|
57
|
12
June 26
|
Yes
|
|
|
|
|
2014
|
57
|
11
June 12
|
Yes
|
|
|
|
|
2014
|
57
|
10
May 22
|
Yes
|
|
|
|
|
2014
|
57
|
9
May 8
|
Yes
|
|
|
|
|
2014
|
57
|
8
April 24
|
Yes
|
|
|
|
|
2014
|
57
|
7
April 10
|
Yes
|
|
|
|
|
2014
|
57
|
6
March 27
|
Yes
|
|
|
|
|
2014
|
57
|
5
March 13. - Hepatitis C Virus Therapies
|
Yes
|
|
|
|
|
2014
|
57
|
4
February 27
|
Yes
|
|
|
|
|
2014
|
57
|
3
February 13
|
Yes
|
|
|
|
|
2014
|
57
|
2
January 23
|
Yes
|
|
|
|
|
2014
|
57
|
1
January 9
|
Yes
|
|
|
|
|
2013
|
56
|
24
December 26
|
Yes
|
|
|
|
|
2013
|
56
|
23
December 12
|
Yes
|
|
|
|
|
2013
|
56
|
22
November 28
|
Yes
|
|
|
|
|
2013
|
56
|
21
November 14
|
Yes
|
|
|
|
|
2013
|
56
|
20
October 24
|
Yes
|
|
|
|
|
2013
|
56
|
19
October 10
|
Yes
|
|
|
|
|
2013
|
56
|
18
September 26
|
Yes
|
|
|
|
|
2013
|
56
|
17
September 12
|
Yes
|
|
|
|
|
2013
|
56
|
16
August 22
|
Yes
|
|
|
|
|
2013
|
56
|
15
August 8
|
Yes
|
|
|
|
|
2013
|
56
|
14
July 25
|
Yes
|
|
|
|
|
2013
|
56
|
13
July 11
|
Yes
|
|
|
|
|
2013
|
56
|
12
June 27
|
Yes
|
|
|
|
|
2013
|
56
|
11
June 13
|
Yes
|
|
|
|
|
2013
|
56
|
10
May 23
|
Yes
|
|
|
|
|
2013
|
56
|
9
May 9
|
Yes
|
|
|
|
|
2013
|
56
|
8
April 25
|
Yes
|
|
|
|
|
2013
|
56
|
7
April 11
|
Yes
|
|
|
|
|
2013
|
56
|
6
March 28
|
Yes
|
|
|
|
|
2013
|
56
|
5
March 14
|
Yes
|
|
|
|
|
2013
|
56
|
4
February 28
|
Yes
|
|
|
|
|
2013
|
56
|
3
February 14
|
Yes
|
|
|
|
|
2013
|
56
|
2
January 24
|
Yes
|
|
|
|
|
2013
|
56
|
1
January 10
|
Yes
|
|
|
|
|
2012
|
55
|
24
December 27
|
Yes
|
|
|
|
|
2012
|
55
|
23
December 13
|
Yes
|
|
|
|
|
2012
|
55
|
22
November 22
|
Yes
|
|
|
|
|
2012
|
55
|
21
November 8. - Alzheimer’s Disease
|
Yes
|
|
|
|
|
2012
|
55
|
20
October 25
|
Yes
|
|
|
|
|
2012
|
55
|
19
October 11
|
Yes
|
|
|
|
|
2012
|
55
|
18
September 27
|
Yes
|
|
|
|
|
2012
|
55
|
17
September 13
|
Yes
|
|
|
|
|
2012
|
55
|
16
August 23
|
Yes
|
|
|
|
|
2012
|
55
|
15
August 9
|
Yes
|
|
|
|
|
2012
|
55
|
14
July 26
|
Yes
|
|
|
|
|
2012
|
55
|
13
July 12
|
Yes
|
|
|
|
|
2012
|
55
|
12
June 28
|
Yes
|
|
|
|
|
2012
|
55
|
11
June 14
|
Yes
|
|
|
|
|
2012
|
55
|
10
May 24
|
Yes
|
|
|
|
|
2012
|
55
|
9
May 10
|
Yes
|
|
|
|
|
2012
|
55
|
8
April 26
|
Yes
|
|
|
|
|
2012
|
55
|
7
April 12
|
Yes
|
|
|
|
|
2012
|
55
|
6
March 22
|
Yes
|
|
|
|
|
2012
|
55
|
5
March 8
|
Yes
|
|
|
|
|
2012
|
55
|
4
February 23
|
Yes
|
|
|
|
|
2012
|
55
|
3
February 9
|
Yes
|
|
|
|
|
2012
|
55
|
2
January 26
|
Yes
|
|
|
|
|
2012
|
55
|
1
January 12
|
Yes
|
|
|
|
|
2011
|
54
|
24
December 22
|
Yes
|
|
|
|
|
2011
|
54
|
23
December 8
|
Yes
|
|
|
|
|
2011
|
54
|
22
November 24
|
Yes
|
|
|
|
|
2011
|
54
|
21
November 10
|
Yes
|
|
|
|
|
2011
|
54
|
20
October 27
|
Yes
|
|
|
|
|
2011
|
54
|
19
October 13
|
Yes
|
|
|
|
|
2011
|
54
|
18
September 22
|
Yes
|
|
|
|
|
2011
|
54
|
17
September 8
|
Yes
|
|
|
|
|
2011
|
54
|
16
August 25
|
Yes
|
|
|
|
|
2011
|
54
|
15
August 11
|
Yes
|
|
|
|
|
2011
|
54
|
14
July 28
|
Yes
|
|
|
|
|
2011
|
54
|
13
July 14
|
Yes
|
|
|
|
|
2011
|
54
|
12
June 23
|
Yes
|
|
|
|
|
2011
|
54
|
11
June 9
|
Yes
|
|
|
|
|
2011
|
54
|
10
May 26
|
Yes
|
|
|
|
|
2011
|
54
|
9
May 12
|
Yes
|
|
|
|
|
2011
|
54
|
8
April 28
|
Yes
|
|
|
|
|
2011
|
54
|
7
April 14
|
Yes
|
|
|
|
|
2011
|
54
|
6
March 24
|
Yes
|
|
|
|
|
2011
|
54
|
5
March 10
|
Yes
|
|
|
|
|
2011
|
54
|
4
February24
|
Yes
|
|
|
|
|
2011
|
54
|
3
February 10
|
Yes
|
|
|
|
|
2011
|
54
|
2
January 27
|
Yes
|
|
|
|
|
2011
|
54
|
1
January 13
|
Yes
|
|
|
|
|
2010
|
53
|
24
December 23
|
Yes
|
|
|
|
|
2010
|
53
|
23
December 9
|
Yes
|
|
|
|
|
2010
|
53
|
22
November 25
|
Yes
|
|
|
|
|
2010
|
53
|
21
November 11
|
Yes
|
|
|
|
|
2010
|
53
|
20
October 28
|
Yes
|
|
|
|
|
2010
|
53
|
19
October 14
|
Yes
|
|
|
|
|
2010
|
53
|
18
September 23
|
Yes
|
|
|
|
|
2010
|
53
|
17
September 9
|
Yes
|
|
|
|
|
2010
|
53
|
16
August 26
|
Yes
|
|
|
|
|
2010
|
53
|
15
August 12
|
Yes
|
|
|
|
|
2010
|
53
|
14
July 22
|
Yes
|
|
|
|
|
2010
|
53
|
13
|
Yes
|
|
|
|
|
2010
|
53
|
12
|
Yes
|
|
|
|
|
2010
|
53
|
11
|
Yes
|
|
|
|
|
2010
|
53
|
10
|
Yes
|
|
|
|
|
2010
|
53
|
9
|
Yes
|
|
|
|
|
2010
|
53
|
8
|
Yes
|
|
|
|
|
2010
|
53
|
7
|
Yes
|
|
|
|
|
2010
|
53
|
6
|
Yes
|
|
|
|
|
2010
|
53
|
5
|
Yes
|
|
|
|
|
2010
|
53
|
4
|
Yes
|
|
|
|
|
2010
|
53
|
3
|
Yes
|
|
|
|
|
2010
|
53
|
2
|
Yes
|
|
|
|
|
2010
|
53
|
1
|
Yes
|
|
|
|
|
2009
|
52
|
24
|
Yes
|
|
|
|
|
2009
|
52
|
23
|
Yes
|
|
|
|
|
2009
|
52
|
22
|
Yes
|
|
|
|
|
2009
|
52
|
21
|
Yes
|
|
|
|
|
2009
|
52
|
20
|
Yes
|
|
|
|
|
2009
|
52
|
19
|
Yes
|
|
|
|
|
2009
|
52
|
18
|
Yes
|
|
|
|
|
2009
|
52
|
17
|
Yes
|
|
|
|
|
2009
|
52
|
16
|
Yes
|
|
|
|
|
2009
|
52
|
15
|
Yes
|
|
|
|
|
2009
|
52
|
14
|
Yes
|
|
|
|
|
2009
|
52
|
13
|
Yes
|
|
|
|
|
2009
|
52
|
12
|
Yes
|
|
|
|
|
2009
|
52
|
11
|
Yes
|
|
|
|
|
2009
|
52
|
10
|
Yes
|
|
|
|
|
2009
|
52
|
9
|
Yes
|
|
|
|
|
2009
|
52
|
8
|
Yes
|
|
|
|
|
2009
|
52
|
7
|
Yes
|
|
|
|
|
2009
|
52
|
6
|
Yes
|
|
|
|
|
2009
|
52
|
5
|
Yes
|
|
|
|
|
2009
|
52
|
4
|
Yes
|
|
|
|
|
2009
|
52
|
3
|
Yes
|
|
|
|
|
2009
|
52
|
2
|
Yes
|
|
|
|
|
2009
|
52
|
1
|
Yes
|
|
|
|
|
2008
|
51
|
24
|
Yes
|
|
|
|
|
2008
|
51
|
23
|
Yes
|
|
|
|
|
2008
|
51
|
22
|
Yes
|
|
|
|
|
2008
|
51
|
21
|
Yes
|
|
|
|
|
2008
|
51
|
20
|
Yes
|
|
|
|
|
2008
|
51
|
19
|
Yes
|
|
|
|
|
2008
|
51
|
18
|
Yes
|
|
|
|
|
2008
|
51
|
17
|
Yes
|
|
|
|
|
2008
|
51
|
16
|
Yes
|
|
|
|
|
2008
|
51
|
15
|
Yes
|
|
|
|
|
2008
|
51
|
14
|
Yes
|
|
|
|
|
2008
|
51
|
13
|
Yes
|
|
|
|
|
2008
|
51
|
12
|
Yes
|
|
|
|
|
2008
|
51
|
11
|
Yes
|
|
|
|
|
2008
|
51
|
10
|
Yes
|
|
|
|
|
2008
|
51
|
9
|
Yes
|
|
|
|
|
2008
|
51
|
8
|
Yes
|
|
|
|
|
2008
|
51
|
7
|
Yes
|
|
|
|
|
2008
|
51
|
6
|
Yes
|
|
|
|
|
2008
|
51
|
5
|
Yes
|
|
|
|
|
2008
|
51
|
4
|
Yes
|
|
|
|
|
2008
|
51
|
3
|
Yes
|
|
|
|
|
2008
|
51
|
2
|
Yes
|
|
|
|
|
2008
|
51
|
1
|
Yes
|
|
|
|
|
2007
|
50
|
26
|
Yes
|
|
|
|
|
2007
|
50
|
25
|
Yes
|
|
|
|
|
2007
|
50
|
24
|
Yes
|
|
|
|
|
2007
|
50
|
23
|
Yes
|
|
|
|
|
2007
|
50
|
22
|
Yes
|
|
|
|
|
2007
|
50
|
21
|
Yes
|
|
|
|
|
2007
|
50
|
20
|
Yes
|
|
|
|
|
2007
|
50
|
19
|
Yes
|
|
|
|
|
2007
|
50
|
18
|
Yes
|
|
|
|
|
2007
|
50
|
17
|
Yes
|
|
|
|
|
2007
|
50
|
16
|
Yes
|
|
|
|
|
2007
|
50
|
15
|
Yes
|
|
|
|
|
2007
|
50
|
14
|
Yes
|
|
|
|
|
2007
|
50
|
13
|
Yes
|
|
|
|
|
2007
|
50
|
12
|
Yes
|
|
|
|
|
2007
|
50
|
11
|
Yes
|
|
|
|
|
2007
|
50
|
10
|
Yes
|
|
|
|
|
2007
|
50
|
9
|
Yes
|
|
|
|
|
2007
|
50
|
8
|
Yes
|
|
|
|
|
2007
|
50
|
7
|
Yes
|
|
|
|
|
2007
|
50
|
6
|
Yes
|
|
|
|
|
2007
|
50
|
5
|
Yes
|
|
|
|
|
2007
|
50
|
4
|
Yes
|
|
|
|
|
2007
|
50
|
3
|
Yes
|
|
|
|
|
2007
|
50
|
2
|
Yes
|
|
|
|
|
2007
|
50
|
1
|
Yes
|
|
|
|
|
2006
|
49
|
26
|
Yes
|
|
|
|
|
2006
|
49
|
25
|
Yes
|
|
|
|
|
2006
|
49
|
24
|
Yes
|
|
|
|
|
2006
|
49
|
23
|
Yes
|
|
|
|
|
2006
|
49
|
22
|
Yes
|
|
|
|
|
2006
|
49
|
21
|
Yes
|
|
|
|
|
2006
|
49
|
20
|
Yes
|
|
|
|
|
2006
|
49
|
19
|
Yes
|
|
|
|
|
2006
|
49
|
18
|
Yes
|
|
|
|
|
2006
|
49
|
17
|
Yes
|
|
|
|
|
2006
|
49
|
16
|
Yes
|
|
|
|
|
2006
|
49
|
15
|
Yes
|
|
|
|
|
2006
|
49
|
14
|
Yes
|
|
|
|
|
2006
|
49
|
13
|
Yes
|
|
|
|
|
2006
|
49
|
12
|
Yes
|
|
|
|
|
2006
|
49
|
11
|
Yes
|
|
|
|
|
2006
|
49
|
10
|
Yes
|
|
|
|
|
2006
|
49
|
9
|
Yes
|
|
|
|
|
2006
|
49
|
8
|
Yes
|
|
|
|
|
2006
|
49
|
7
|
Yes
|
|
|
|
|
2006
|
49
|
6
|
Yes
|
|
|
|
|
2006
|
49
|
4
-5
|
Yes
|
|
|
|
|
2006
|
49
|
3
|
Yes
|
|
|
|
|
2006
|
49
|
2
|
Yes
|
|
|
|
|
2006
|
49
|
1
|
Yes
|
|
|
|
|
2005
|
48
|
26
|
Yes
|
|
|
|
|
2005
|
48
|
25
|
Yes
|
|
|
|
|
2005
|
48
|
24
|
Yes
|
|
|
|
|
2005
|
48
|
23
|
Yes
|
|
|
|
|
2005
|
48
|
22
|
Yes
|
|
|
|
|
2005
|
48
|
21
|
Yes
|
|
|
|
|
2005
|
48
|
20
|
Yes
|
|
|
|
|
2005
|
48
|
19
|
Yes
|
|
|
|
|
2005
|
48
|
18
|
Yes
|
|
|
|
|
2005
|
48
|
17
|
Yes
|
|
|
|
|
2005
|
48
|
16
|
Yes
|
|
|
|
|
2005
|
48
|
15
|
Yes
|
|
|
|
|
2005
|
48
|
14
|
Yes
|
|
|
|
|
2005
|
48
|
13
|
Yes
|
|
|
|
|
2005
|
48
|
12
|
Yes
|
|
|
|
|
2005
|
48
|
11
|
Yes
|
|
|
|
|
2005
|
48
|
10
|
Yes
|
|
|
|
|
2005
|
48
|
9
|
Yes
|
|
|
|
|
2005
|
48
|
8
|
Yes
|
|
|
|
|
2005
|
48
|
7
|
Yes
|
|
|
|
|
2005
|
48
|
6
|
Yes
|
|
|
|
|
2005
|
48
|
5
|
Yes
|
|
|
|
|
2005
|
48
|
4
|
Yes
|
|
|
|
|
2005
|
48
|
3
|
Yes
|
|
|
|
|
2005
|
48
|
2
|
Yes
|
|
|
|
|
2005
|
48
|
1
|
Yes
|
|
|
|
|
2004
|
47
|
27
|
Yes
|
|
|
|
|
2004
|
47
|
26
|
Yes
|
|
|
|
|
2004
|
47
|
25
|
Yes
|
|
|
|
|
2004
|
47
|
24
|
Yes
|
|
|
|
|
2004
|
47
|
23
|
Yes
|
|
|
|
|
2004
|
47
|
22
|
Yes
|
|
|
|
|
2004
|
47
|
21
|
Yes
|
|
|
|
|
2004
|
47
|
20
|
Yes
|
|
|
|
|
2004
|
47
|
19
|
Yes
|
|
|
|
|
2004
|
47
|
18
|
Yes
|
|
|
|
|
2004
|
47
|
14
-17
|
Yes
|
|
|
|
|
2004
|
47
|
13
|
Yes
|
|
|
|
|
2004
|
47
|
12
|
Yes
|
|
|
|
|
2004
|
47
|
11
|
Yes
|
|
|
|
|
2004
|
47
|
10
|
Yes
|
|
|
|
|
2004
|
47
|
9
|
Yes
|
|
|
|
|
2004
|
47
|
8
|
Yes
|
|
|
|
|
2004
|
47
|
7
|
Yes
|
|
|
|
|
2004
|
47
|
6
|
Yes
|
|
|
|
|
2004
|
47
|
5
|
Yes
|
|
|
|
|
2004
|
47
|
4
|
Yes
|
|
|
|
|
2004
|
47
|
3
|
Yes
|
|
|
|
|
2004
|
47
|
2
|
Yes
|
|
|
|
|
2004
|
47
|
1
|
Yes
|
|
|
|
|
2003
|
46
|
26
|
Yes
|
|
|
|
|
2003
|
46
|
25
|
Yes
|
|
|
|
|
2003
|
46
|
24
|
Yes
|
|
|
|
|
2003
|
46
|
23
|
Yes
|
|
|
|
|
2003
|
46
|
22
|
Yes
|
|
|
|
|
2003
|
46
|
21
|
Yes
|
|
|
|
|
2003
|
46
|
20
|
Yes
|
|
|
|
|
2003
|
46
|
19
|
Yes
|
|
|
|
|
2003
|
46
|
18
|
Yes
|
|
|
|
|
2003
|
46
|
17
|
Yes
|
|
|
|
|
2003
|
46
|
16
|
Yes
|
|
|
|
|
2003
|
46
|
15
|
Yes
|
|
|
|
|
2003
|
46
|
14
|
Yes
|
|
|
|
|
2003
|
46
|
13
|
Yes
|
|
|
|
|
2003
|
46
|
12
|
Yes
|
|
|
|
|
2003
|
46
|
11
|
Yes
|
|
|
|
|
2003
|
46
|
10
|
Yes
|
|
|
|
|
2003
|
46
|
8
-9
|
Yes
|
|
|
|
|
2003
|
46
|
7
|
Yes
|
|
|
|
|
2003
|
46
|
6
|
Yes
|
|
|
|
|
2003
|
46
|
5
|
Yes
|
|
|
|
|
2003
|
46
|
4
|
Yes
|
|
|
|
|
2003
|
46
|
3
|
Yes
|
|
|
|
|
2003
|
46
|
2
|
Yes
|
|
|
|
|
2003
|
46
|
1
|
Yes
|
|
|
|
|
2002
|
45
|
26
|
Yes
|
|
|
|
|
2002
|
45
|
25
|
Yes
|
|
|
|
|
2002
|
45
|
24
|
Yes
|
|
|
|
|
2002
|
45
|
23
|
Yes
|
|
|
|
|
2002
|
45
|
22
|
Yes
|
|
|
|
|
2002
|
45
|
21
|
Yes
|
|
|
|
|
2002
|
45
|
20
|
Yes
|
|
|
|
|
2002
|
45
|
19
|
Yes
|
|
|
|
|
2002
|
45
|
18
|
Yes
|
|
|
|
|
2002
|
45
|
17
|
Yes
|
|
|
|
|
2002
|
45
|
16
|
Yes
|
|
|
|
|
2002
|
45
|
15
|
Yes
|
|
|
|
|
2002
|
45
|
14
|
Yes
|
|
|
|
|
2002
|
45
|
13
|
Yes
|
|
|
|
|
2002
|
45
|
12
|
Yes
|
|
|
|
|
2002
|
45
|
11
|
Yes
|
|
|
|
|
2002
|
45
|
10
|
Yes
|
|
|
|
|
2002
|
45
|
1
-9
|
Yes
|
|
|
|
|
2001
|
44
|
1
-26
|
Yes
|
|
|
|
|
2000
|
43
|
1
-26
|
Yes
|
|
|
|
|
1999
|
42
|
1
-26
|
Yes
|
|
|
|
|
1998
|
41
|
1
-27
|
Yes
|
|
|
|
|
1997
|
40
|
1
-26
|
Yes
|
|
|
|
|
1996
|
39
|
1
-26
|
Yes
|
|
|
|
|
1977-1995
|
20-38
|
|
Yes
|
|
|
|
